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bap 1  (Santa Cruz Biotechnology)


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    Structured Review

    Santa Cruz Biotechnology bap 1
    Bap 1, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 725 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bap+1/BRCA1/pm41712014-43-4-12
    Average 96 stars, based on 725 article reviews
    bap 1 - by Bioz Stars, 2026-09
    96/100 stars

    Images

    Related Articles

    Immunohistochemistry:

    Article Title: Splenic hamartoma in two related patients with BAP1 tumour predisposition syndrome caused by a novel germline BAP1 p.(Gly128Arg) missense variant.
    Article Snippet: .. BAP1 IHC IHC with BAP-1 (BRCA1-Associated Protein 1) antibody, clone C-4, from Santa Cruz Biotechnology (Texas, USA) was performed on FFPE tissue slides from the patient’s RCC, splenic hamartoma, uterine leiomyoma, and three skin lesions, and the first-degree relative’s spleen. ..

    Article Title: Splenic hamartoma in two related patients with BAP1 tumour predisposition syndrome caused by a novel germline BAP1 p.(Gly128Arg) missense variant
    Article Snippet: .. IHC with BAP-1 (BRCA1-Associated Protein 1) antibody, clone C-4, from Santa Cruz Biotechnology (Texas, USA) was performed on FFPE tissue slides from the patient’s RCC, splenic hamartoma, uterine leiomyoma, and three skin lesions, and the first-degree relative’s spleen. ..

    Formalin-fixed Paraffin-Embedded:

    Article Title: Splenic hamartoma in two related patients with BAP1 tumour predisposition syndrome caused by a novel germline BAP1 p.(Gly128Arg) missense variant.
    Article Snippet: .. BAP1 IHC IHC with BAP-1 (BRCA1-Associated Protein 1) antibody, clone C-4, from Santa Cruz Biotechnology (Texas, USA) was performed on FFPE tissue slides from the patient’s RCC, splenic hamartoma, uterine leiomyoma, and three skin lesions, and the first-degree relative’s spleen. ..

    Article Title: Splenic hamartoma in two related patients with BAP1 tumour predisposition syndrome caused by a novel germline BAP1 p.(Gly128Arg) missense variant
    Article Snippet: .. IHC with BAP-1 (BRCA1-Associated Protein 1) antibody, clone C-4, from Santa Cruz Biotechnology (Texas, USA) was performed on FFPE tissue slides from the patient’s RCC, splenic hamartoma, uterine leiomyoma, and three skin lesions, and the first-degree relative’s spleen. ..

    other:

    Article Title: DNA Damage Repair in Glioblastoma: A Novel Approach to Combat Drug Resistance
    Article Snippet: BAP‐1 , Mouse monoclonal anti‐BAP1 (Santa Cruz Biotechnology, Dallas, USA) , 1:200.

    Staining:

    Article Title: Mesothelin expression remodeled the immune-matrix tumor microenvironment predicting the risk of death in patients with malignant pleural mesothelioma
    Article Snippet: .. TMA sections (N = 82) were stained with immunoperoxidase and antibodies against the following proteins: MSLN (1:150; Biocare), D2-40 (1:1000; Dako); WT-1 (pre-diluted; Cellmarque); BAP-1 (pre-diluted, Santa Cruz); CD4 (1: 50, Novocastra), CD8 (1:400; Dako); CD68 (1:5000; Dako); PD-L1 (pre-diluted; Roche); and elastin (1:100; Santa Cruz). .. After preparation, the slides were analyzed under light microscopy to confirm reactivity and then digitally scanned at 40× magnification using a Pannoramic 250 scanner (3DHistech, Budapest, Hungary).

    Article Title: An Atypical Deep Penetrating Nevus With Mutations in Beta Catenin, BRAF V600E , and IDH1 R132C in an 8-Year-Old Boy
    Article Snippet: Deep penetrating nevus (DPN) is a pigmented melanocytic tumor which typically displays a wedge-shaped deep penetrating architecture.. Some cases show a coexisting component resembling conventional melanocytic nevus.. These morphological attributes are correlated with the acquisition of genomic alterations in the Wnt pathway on a background of underlying activating MAPK pathway mutations.

    Article Title: Histopathologic and molecular characterization of BAP-1-inactivated melanoma.
    Article Snippet: .. Standardized automated immunohistochemical staining platforms were utilized (Leica BOND III, Leica Biosystems) along with commercially available antibodies for BAP-1 (University of Virginia: Clone-C4, Santa Cruz, dilution 1:750, REF# SC-28383; Dartmouth: Clone-C4, Santa Cruz, dilution 1:150, REF# SC-28383). .. Once the cases were selected, the tissue from each case was examined with OncoScan Assay (ThermoFisher Scientific), a microarray assay that performs whole-genome copy number analysis along with a somatic mutation panel.

    Immunohistochemical staining:

    Article Title: Histopathologic and molecular characterization of BAP-1-inactivated melanoma.
    Article Snippet: .. Standardized automated immunohistochemical staining platforms were utilized (Leica BOND III, Leica Biosystems) along with commercially available antibodies for BAP-1 (University of Virginia: Clone-C4, Santa Cruz, dilution 1:750, REF# SC-28383; Dartmouth: Clone-C4, Santa Cruz, dilution 1:150, REF# SC-28383). .. Once the cases were selected, the tissue from each case was examined with OncoScan Assay (ThermoFisher Scientific), a microarray assay that performs whole-genome copy number analysis along with a somatic mutation panel.



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    FIGURE 3 | Proliferation and DNA repair activity. Immunolabelling for PCNA and PARP1 (in green) and <t>BAP1</t> (in red): In the control condition and differently treated GSCs, that is, after 48 h-CT Cisplatin 40 μM or Pt(IV)Ac-POA 10 μM. DNA was stained with Hoechst 33,258 (blue fluores- cence). Magnification 25×, bar of 40 μm. The histograms show the mean fluorescence intensity value of the immunolabelling ± SEM for (A) PCNA, (B) PARP1, and (C) BAP1. Statistical significance calculated as follows: ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.1.
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    FIGURE 3 | Proliferation and DNA repair activity. Immunolabelling for PCNA and PARP1 (in green) and <t>BAP1</t> (in red): In the control condition and differently treated GSCs, that is, after 48 h-CT Cisplatin 40 μM or Pt(IV)Ac-POA 10 μM. DNA was stained with Hoechst 33,258 (blue fluores- cence). Magnification 25×, bar of 40 μm. The histograms show the mean fluorescence intensity value of the immunolabelling ± SEM for (A) PCNA, (B) PARP1, and (C) BAP1. Statistical significance calculated as follows: ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.1.
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    FIGURE 3 | Proliferation and DNA repair activity. Immunolabelling for PCNA and PARP1 (in green) and <t>BAP1</t> (in red): In the control condition and differently treated GSCs, that is, after 48 h-CT Cisplatin 40 μM or Pt(IV)Ac-POA 10 μM. DNA was stained with Hoechst 33,258 (blue fluores- cence). Magnification 25×, bar of 40 μm. The histograms show the mean fluorescence intensity value of the immunolabelling ± SEM for (A) PCNA, (B) PARP1, and (C) BAP1. Statistical significance calculated as follows: ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.1.
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    Image Search Results


    FIGURE 3 | Proliferation and DNA repair activity. Immunolabelling for PCNA and PARP1 (in green) and BAP1 (in red): In the control condition and differently treated GSCs, that is, after 48 h-CT Cisplatin 40 μM or Pt(IV)Ac-POA 10 μM. DNA was stained with Hoechst 33,258 (blue fluores- cence). Magnification 25×, bar of 40 μm. The histograms show the mean fluorescence intensity value of the immunolabelling ± SEM for (A) PCNA, (B) PARP1, and (C) BAP1. Statistical significance calculated as follows: ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.1.

    Journal: Cell proliferation

    Article Title: DNA Damage Repair in Glioblastoma: A Novel Approach to Combat Drug Resistance.

    doi: 10.1111/cpr.13815

    Figure Lengend Snippet: FIGURE 3 | Proliferation and DNA repair activity. Immunolabelling for PCNA and PARP1 (in green) and BAP1 (in red): In the control condition and differently treated GSCs, that is, after 48 h-CT Cisplatin 40 μM or Pt(IV)Ac-POA 10 μM. DNA was stained with Hoechst 33,258 (blue fluores- cence). Magnification 25×, bar of 40 μm. The histograms show the mean fluorescence intensity value of the immunolabelling ± SEM for (A) PCNA, (B) PARP1, and (C) BAP1. Statistical significance calculated as follows: ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.1.

    Article Snippet: Antigen Primary antibody Dilution PCNA Mouse monoclonal [PC10] antiPCNA (Abcam, Cambridge, UK) 1:200 PARP- 1 Rabbit polyclonal antiPARP- 1 (Cell Signalling Technology, Danvers, USA) 1:200 BAP- 1 Mouse monoclonal anti- BAP1 (Santa Cruz Biotechnology, Dallas, USA) 1:200 HIF- 1α Rabbit monoclonal anti- HIF- 1α (D1S7W) (Cell Signalling Technology, Danvers, USA) 1:200 AIF Rabbit polyclonal anti- AIF (Cell Signalling Technology, Danvers, USA) 1:200 COX- 2 Mouse polyclonal antiCOX2 (M- 19) (Santa Cruz Biotechnology, Dallas, USA) 1:200 SOD- 2 Rabbit monoclonal antiSOD2 (Cell Signalling Technology, Danvers, USA) 1:200 GPx- 4 Rabbit polyclonal anti- GPx4 (Abcam, Cambridge, UK) 1:200 13652184, 0, D ow nloaded from https://onlinelibrary.w iley.com /doi/10.1111/cpr.13815 by IN A SP - N E PA L , W iley O nline L ibrary on [02/02/2025].

    Techniques: Activity Assay, Control, Staining, Fluorescence